Antidepressant agents work by supporting neurotransmitter balance, calming the nervous system, or uplifting the mind and spirit. Herbs with antidepressant properties often have adaptogenic, nervine, or mood-enhancing effects. St. John’s Wort (Hypericum perforatum) is well-known for its ability to support emotional well-being by influencing serotonin and dopamine pathways. Ashwagandha (Withania somnifera) is an adaptogen that reduces stress and promotes emotional resilience. Lemon balm (Melissa officinalis) is traditionally used to calm anxiety and uplift mood. These herbs provide a natural approach to managing feelings of sadness, fatigue, or overwhelm, helping to restore a sense of balance and joy.